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UBIQUITIN-PROTEIN LIGASE COMPLEXES
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DeCS
Descriptor
English
:
Ubiquitin-Protein Ligase Complexes
Descriptor
Spanish
:
Complejos de Ubiquitina-Proteína Ligasa
Descriptor
Portuguese
:
Complexos Ubiquitina-Proteína Ligase
Synonyms
English
:
Complexes, Ubiquitin-Protein Ligase
Ligase Complexes, Ubiquitin-Protein
Ubiquitin Protein Ligase Complexes
Tree Number:
D08.811.464.938
Definition
English
:
Complexes of
enzymes
that catalyze the covalent attachment of
UBIQUITIN
to other
proteins
by forming a peptide bond between the C-terminal
GLYCINE
of
UBIQUITIN
and the alpha-amino groups of
LYSINE
residues in the protein. The complexes play an important role in mediating the selective-degradation of short-lived and abnormal
proteins
. The complex of
enzymes
can be broken down into three components that involve activation of
ubiquitin
(
UBIQUITIN-ACTIVATING ENZYMES
), conjugation of
ubiquitin
to the ligase complex (
UBIQUITIN-CONJUGATING ENZYMES
), and
ligation
of
ubiquitin
to the substrate protein (
UBIQUITIN-PROTEIN LIGASES
).
Indexing Annotation
English
:
UBIQUITIN-PROTEIN LIGASES
is also available
History Note
English
:
2004
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
38180
Unique Identifier:
D043743
Occurrence in VHL
:
Similar:
DeCS
CID-10
LILACS